At the very least one could determine that they are unaltered, but were getting into super cool levels of forensic analysis into determining whether the layers of ink on top match the chemical composition of the ink layers on bottom
You can also play the Themed format, which is the least used format
While one strategy may be to horde a bunch of counters and swing out in one big turn, the untap effect is likely more potent
These are prime examples of what works best with Muldrotha effects on permanents that put themselves into the graveyard, allowing you to replay them again and again
Demilich An astute viewer might notice a trend in a few of my choices and have a bone to pick with me, but I can assure you that the fanciest of all skulls is a fun and aggressive value engine
The most famous is Serum Powder while it's in your opening hand, you may exile that entire hand and draw that many cards, effectively a free extra mulligan